Department of Biological Sciences, University of Limerick, Limerick, Ireland
Received 28 October 2016, Accepted 2 February 2017, Available online 23 March 2017
product consumption is often associated with negative effects because
of its naturally high levels of saturated fatty acids. However, recent
research has shown that dairy lipids possess putative bioactivity
against chronic inflammation. Inflammation triggers the onset of several
chronic diseases, including cardiovascular disease, type 2 diabetes
mellitus, obesity, and cancer. This review discusses the
anti-inflammatory properties of dairy lipids found in milk, yogurt, and
cheese, and it examines them in relation to their implications for human
health: their protective effects and their role in pathology. We also
consider the effect of lipid profile alteration in dairy products—by
using ruminant dietary strategies to enrich the milk, or by lipid
fortification in the products. We critically review the in vivo, in
vitro, ex vivo, and epidemiological studies associated with these dairy
lipids and their role in various inflammatory conditions. Finally, we
discuss some suggestions for future research in the study of bioactive
lipids and dairy products, with reference to the novel field of
metabolomics and epidemiological studies.
Statin therapy increases the risk of new-onset diabetes in elderly women
by 33%, and the higher the dose, the greater the risk, new research shows.
The title of the paper is:New-Onset Diabetes After Statin Exposure in Elderly Women: The Australian Longitudinal Study on Women’s Health
and its implications are rather significant.
"GPs and their elderly female patients should be aware of the risks,"
Dr Jones added in a University of Queensland statement, noting that
those elderly women taking statins "should be carefully and regularly
monitored for increased blood glucose to ensure early detection and
management of diabetes."
And, he and his colleagues suggest, it may be the case that statins could be stopped altogether in some elderly women.
"What's most concerning was that we found a 'dose effect,' where the
risk of diabetes increased as the dosage of statins increased, [and]
over the 10 years of the study, most of the women progressed to higher
doses of statins," Dr Jones observed.
and his colleagues therefore recommend that ongoing risk assessment is
"critical" to ensure optimal health outcomes and quality of life in
I read with interest the news on evolocumab and a large international trial on 27,000 patients.
The British Heart Foundation said the findings were a significant advance in fighting the biggest killer in the world.
The study found that for every 74 people who took the drug for two years, one heart attack or stroke would be prevented. However, the findings, published in the New England Journal of Medicine, found that the drug had no impact on the rate of
Looking for a new drug to lower LDL is a sign that quite few people have now accepted that statins do not work...but addressing CVDs from the same point of view (i.e. LDL) is the fundamental problem as described here and here.
So, are we still at square one?
I am afraid we are...as long we believe that LDL is the problem...
A novel approach is badly needed...
(an approach that we describe in the book we are writing...)
The identification of hazards, the
evaluation of their risks and the putting in place of control measures
to secure the health and safety of employees is a major element for
managing health and safety under the Safety, Health and Welfare at Work
The Chemical Agent Regulations 2001 point out the specific requirements necessary to complete a Chemical Agents risk assessment of the chemical agents used in the work place.
The Risk Assessment steps:
Identify the chemical hazards.
Consider who might be affected and how they might be harmed.
Evaluate the risks,- what are you doing now and what further precautions are needed?
contrast to the current belief that cholesterol reduction with statins
decreases atherosclerosis, we present a perspective that statins may be
causative in coronary artery calcification and can function as
mitochondrial toxins that impair muscle function in the heart and blood
vessels through the depletion of coenzyme Q10 and 'heme A', and thereby
ATP generation. Statins inhibit the synthesis of vitamin K2, the
cofactor for matrix Gla-protein activation, which in turn protects
arteries from calcification. Statins inhibit the biosynthesis of
selenium containing proteins, one of which is glutathione peroxidase
serving to suppress peroxidative stress. An impairment of selenoprotein
biosynthesis may be a factor in congestive heart failure, reminiscent of
the dilated cardiomyopathies seen with selenium deficiency. Thus, the
epidemic of heart failure and atherosclerosis that plagues the modern
world may paradoxically be aggravated by the pervasive use of statin
drugs. We propose that current statin treatment guidelines be critically
In Aquafarming industry, as in every other, some of the burning questions we
face every day are around cost analysis, supply management and branding
However some of the rather hidden opportunities could be around the nutritional
value of products and how these products can be better branded and marketed in
a challenging environment where borders are virtually non-existent.
One of the issues that I remind my students often about is the use of hurdle
technology in order to maximise shelf-file and therefore increase the size of
the potential markets where we can sell our products.
Modified Atmosphere Packaging (MAP) is an excellent tool to prolong shelf life.
MAP can give fish fillets an expiry date about 7-9 days from day of production.
Therefore, the product can practically travel around the globe!
With this in mind, let’s have a look at some of the new challenges that lie
Challenge one: Marine Pathogens
The aquaculture industry is constantly expanding to meet the needs of the
global population and ever growing demand for quality protein. Economic
sustainability of this industry requires an increasing diversification of
cultured fish species.
A prerequisite of the introduction of new species to aquaculture is the
development of larval cultures and assessing their growth and health on
exposure to water from the open sea.
The semi-intensive “mesocosm” technique can be used to determine the specific
biological, ecological and nutritional needs of each species, as rearing
methodologies used in other established species may not be applicable.
Under the technique, unfiltered seawater is supplied to tanks in order to
enhance natural planktonic productivity, providing live feed prey to the fish
larvae in addition to supplements of cultured live feeds such as rotifers or
Artemia. Read the full article HERE.